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Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 187-219 doi: 10.1007/s11684-015-0386-y

Abstract:

Autoimmune hepatitis is a chronic liver disease putatively caused by loss of tolerance to hepatocyte-specificSince many features also occur in other chronic liver diseases, these scoring systems aid evaluationLiver transplantation represents a life-saving option for patients presenting with acute liver failure

Keywords： autoimmune hepatitis     autoantibodies     diagnosis     immunological diseases     drug-induced liver injury     therapy     immunosuppression     outcomes     hepatocellular carcinoma     liver transplantation    

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Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-knownliver-restorative herb

Jiabo Wang,Zhijie Ma,Ming Niu,Yun Zhu,Qingsheng Liang,Yanling Zhao,Jingyuan Song,Zhaofang Bai,Yaming Zhang,Ping Zhang,Na Li,Yakun Meng,Qi Li,Lushan Qin,Guangju Teng,Junling Cao,Baosen Li,Shilin Chen,Yonggang Li,Zhengsheng Zou,Honghao Zhou,Xiaohe Xiao

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 457-467 doi: 10.1007/s11684-015-0417-8

Abstract:

Herbal medicines have recently been recognized as the second most common cause of drug-induced liverinjury (DILI) in the United States.In this study, a total of 12 307 inpatients with liver dysfunction and 147 literature-reported cases

Keywords： drug-induced liver injury     pharmacognosy     metabolomics     stilbene     Polygonum multiflorum     Chinese herbal    

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Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 104-111 doi: 10.1007/s11684-017-0568-x

Abstract: effect of Rdh13 on liver injury induced by carbon tetrachloride (CCl ).Although Rdh13 deficiency showed no significant effect on liver histology and physiological functionsunder regular culture, the mice displayed an attenuated response to CCl -induced liver injury.Furthermore, the mice had Rdh13 deficiency and thus their liver cells were protected from apoptosisinjury.

Keywords： retinol dehydrogenase 13     carbon tetrachloride     acute liver injury     Cyp2e1     Spot14    

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Studies of the Guiyuan Fang and Autologous Bone Marrow Stem Cells Transplantation on Hepatic Injury and

Wu Limao,Li Lianda,Liu Hong,Ning Keyong,Li Yikui

Strategic Study of CAE 2004, Volume 6, Issue 7,   Pages 34-42

Abstract: Methods Acute localized liver injury model was induced in rabbits by injecting ethanol locally, and theliver fibrosis models were reproduced by complex factors (high lipid, low protein, alcohol, CClLiver function was assessed by measurement ALT, AST, TP, ALB, and GST.Results In the acute liver injury experiment, the reduction of serum GST levels was remarkable in allparenchyma, along with expression of cytokeratin-18，the liver epithelial specific marker.

Keywords： bone marrow stem cells     autologous transplantation     liver injury     liver fibrosis     guiyuan fang    

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Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 368-373 doi: 10.1007/s11684-015-0403-1

Abstract: ) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injuryHowever, its protective abilities against I/R injury in the liver are unknown.We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats.Blood samples and tissue specimens from the liver were obtained.Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury.

Keywords： ischemia/reperfusion     liver     glucagon-like peptide-2     alanine aminotransferase    

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Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity Article

Qiusha Pan, Peifang Song, Zhenhua Ni, Xingkai Qian, Anqi Wang, Liwei Zou, Yong Liu, Ping Wang, Weidong Zhang, Hong Ma, Ling Yang

Engineering 2022, Volume 19, Issue 12,   Pages 153-165 doi: 10.1016/j.eng.2021.09.014

Abstract:

Accurately assessing and tracking the progression of liver-specific injury remains a major challengeinjury.effects than QFPDD, whereas QFPDD was more effective in blocking liver inflammation and repairing liverinjury–an application that allows for the differentiation of liver damage and inflammatory liverinjury.

Keywords： Carboxylesterase 1     Dipeptidyl peptidase 4     Liver injury     Validation tracking    

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Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 111-125 doi: 10.1007/s11684-021-0854-5

Abstract: Although mixed liver impairment has been reported in COVID-19 patients, the association of liver injuryIn addition to previously reported liver impairment markers, such as alanine aminotransferase, aspartate

Keywords： COVID-19     chronic hepatitis B     liver injury     coagulation dysfunction    

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Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 508-511 doi: 10.1007/s11684-015-0418-7

Abstract:

Bile duct injury is a common complication of cholecystectomy.The timing of bile duct injury repair remains controversial.Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommendedendoscopic stenting are the mainstays of treatment of bile leak because they convert acute bile duct injury

Keywords： bile duct injury     cholecystectomy     laparoscopic cholecystectomy    

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Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury

Yanli LIU, Rong LIU, Cheng ZHEN, Quanfang GUO, Liping WU, Zhaoxi DING, Yushun BI, Zhiyu LIU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 91-95 doi: 10.1007/s11684-009-0011-z

Abstract: To study the efficacy of Fuganling granula (FGL, 复肝灵颗粒) in treating mouse immunological hepatic injuryinjury model and then were randomly divided into 5 groups (10 mice/group): 4 groups received treatmentThe liver index and spleen index increased significantly.This experiment established the immunological liver injury model successfully and found that FGL hasa remarkably protective effect on this kind of immunological hepatic injury.

Keywords： Fuganling granula     immunological liver injury     bacille calmette guerin     lipopolysaccharide     mice    

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Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 1-7 doi: 10.1007/s11684-010-0105-7

Abstract:

Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques becauseSplit liver transplantation provides chances to two or even more recipients when only one liver graftBefore surgery, a series of donor evaluations—including anatomical, liver volume, and liver functionAt different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver

Keywords： partial liver transplantation     reduced-size liver transplantation     split liver transplantation     living donorliver transplantation    

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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract: γδ T cells are enriched in the liver and exhibit liver-specific features.fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regenerationWe believe that determining the properties and functions of γδ T cells in liver diseasesenhances our understanding of the pathogenesis of liver diseases and is useful for the design of novelγδ T cell-based therapeutic regimens for liver diseases.

Keywords： γδT cells     liver infection     non-alcoholic fatty liver disease     autoimmune hepatitis     liver fibrosis and cirrhosis     liver cancer     liver regeneration    

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Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 887-902 doi: 10.1007/s11684-021-0879-9

Abstract: Subarachnoid hemorrhage (SAH) induces white matter injury, but the involvement of MCT1 is unclear.the SAH model of adult male Sprague-Dawley rats was used to explore the role of MCT1 in white matter injury

Keywords： microRNAs     monocarboxylate transporter 1     motor training     subarachnoid hemorrhage     white matter injury    

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Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 393-402 doi: 10.1007/s11684-017-0532-9

Abstract:

The risk factors, especially laboratory indicators, of prognosis after acute kidney injury (AKI) remain

Keywords： acute kidney injury     risk factors     prognosis    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the livernatural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liverdiseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma.and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholicliver disease     nonalcoholic fatty liver disease     hepatocellular carcinoma    

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract:

The liver has been characterized as a frontline lymphoid organ with complex immunological featuressuch as liver immunity and liver tolerance.Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infectionThe liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypicUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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Title Author Date Type Operation

Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Journal Article

Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-knownliver-restorative herb

Jiabo Wang,Zhijie Ma,Ming Niu,Yun Zhu,Qingsheng Liang,Yanling Zhao,Jingyuan Song,Zhaofang Bai,Yaming Zhang,Ping Zhang,Na Li,Yakun Meng,Qi Li,Lushan Qin,Guangju Teng,Junling Cao,Baosen Li,Shilin Chen,Yonggang Li,Zhengsheng Zou,Honghao Zhou,Xiaohe Xiao

Journal Article

Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Journal Article

Studies of the Guiyuan Fang and Autologous Bone Marrow Stem Cells Transplantation on Hepatic Injury and

Wu Limao,Li Lianda,Liu Hong,Ning Keyong,Li Yikui

Journal Article

Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Journal Article

Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity

Qiusha Pan, Peifang Song, Zhenhua Ni, Xingkai Qian, Anqi Wang, Liwei Zou, Yong Liu, Ping Wang, Weidong Zhang, Hong Ma, Ling Yang

Journal Article

Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study

Journal Article

Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Journal Article

Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury

Yanli LIU, Rong LIU, Cheng ZHEN, Quanfang GUO, Liping WU, Zhaoxi DING, Yushun BI, Zhiyu LIU

Journal Article

Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Journal Article

γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Journal Article

Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid

Journal Article

Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article